Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones.
نویسندگان
چکیده
Twenty-nine fluoroquinolone (FQ)-resistant clinical isolates of Streptococcus pneumoniae from a collection of isolates from the Alexander Project (1992-1997) and a study from Northern Ireland were identified on the basis of ofloxacin MICs > or = 4 mg/L. DNA fingerprint analyses using BOX-fingerprinting and pulsed-field gel electrophoresis revealed serotype 9V and 23F high-level FQ-resistant strains indistinguishable from the pandemic Spain(23F)-1 and Spain(9V)-3 clones, the type strains of which are low-level resistant or susceptible to the fluoroquinolones.
منابع مشابه
Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones
Antibiotic resistance in Streptococcus pneumoniae has increased worldwide by the spread of a few clones. Fluoroquinolone resistance occurs mainly by alteration of their intracellular targets, the type II DNA topoisomerases, which is acquired either by point mutation or by recombination. Increase in fluoroquinolone-resistance may depend on the balance between antibiotic consumption and the cost ...
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عنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 49 1 شماره
صفحات -
تاریخ انتشار 2002